Masashi Yanagisawa Selected Research

Sleep Wake Disorders

1/2019	Toward the Mysteries of Sleep.
10/2015	Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.
11/2014	Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway.
2/2014	Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.
4/2011	Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice.
1/2009	IGFBP3 colocalizes with and regulates hypocretin (orexin).
10/2008	Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice.
6/2005	Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions.
8/2004	Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity.
5/2004	Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat.

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Masashi Yanagisawa Research Topics

Disease

30	Narcolepsy 01/2022 - 06/2002
15	Cataplexy 01/2021 - 06/2003
12	Sleep Wake Disorders 01/2019 - 06/2002
11	Hypertension (High Blood Pressure) 12/2019 - 08/2002
7	Body Weight (Weight, Body) 10/2019 - 08/2004
7	Obesity 10/2019 - 12/2003
6	Sleepiness 01/2019 - 07/2004
6	Insulin Resistance 11/2016 - 05/2003
6	Cardiomegaly (Heart Hypertrophy) 01/2014 - 02/2004
5	Inflammation (Inflammations) 10/2022 - 01/2005
5	Pulmonary Arterial Hypertension 01/2021 - 10/2012
5	Pulmonary Hypertension 01/2021 - 04/2002
5	Sleep Deprivation 01/2021 - 12/2014
5	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2021 - 01/2017
5	Neoplasms (Cancer) 12/2019 - 08/2008
5	Disorders of Excessive Somnolence (Hypersomnia) 11/2018 - 04/2008
5	Hypertrophy 09/2014 - 02/2004
4	Hypoxia (Hypoxemia) 01/2021 - 04/2002
4	Pain (Aches) 05/2016 - 01/2005
4	Fibrosis (Cirrhosis) 01/2016 - 06/2010
4	Metrorrhagia (Spotting) 11/2004 - 09/2002
3	Heart Failure 12/2019 - 01/2014
3	Diabetic Nephropathies (Diabetic Nephropathy) 12/2019 - 04/2006
3	Hypothermia 01/2016 - 02/2009
3	Albuminuria 05/2014 - 04/2006
3	Wounds and Injuries (Trauma) 01/2014 - 06/2004
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2009 - 12/2003
3	Chronic Kidney Failure (Chronic Renal Failure) 01/2006 - 06/2004
2	Alzheimer Disease (Alzheimer's Disease) 03/2022 - 12/2014
2	AIDS-Related Complex (ARC) 12/2020 - 03/2004
2	Jet Lag Syndrome 10/2019 - 11/2018
2	Nervous System Diseases (Neurological Disorders) 01/2018 - 06/2003
2	Type 2 Diabetes Mellitus (MODY) 11/2016 - 01/2016
2	Systemic Scleroderma (Systemic Sclerosis) 01/2016 - 01/2014
2	Sclerosis 01/2016 - 05/2014
2	DiGeorge Syndrome (Syndrome, DiGeorge) 10/2010 - 09/2003
2	Hyperphagia (Overeating) 05/2010 - 05/2003
2	Weight Gain 02/2009 - 08/2004
2	Sleep Apnea Syndromes (Sleep Apnea) 02/2008 - 01/2007
2	Hyperalgesia 07/2005 - 01/2005
2	Heart Diseases (Heart Disease) 04/2005 - 08/2002
2	Cardiomyopathies (Cardiomyopathy) 04/2005 - 08/2002
1	Familial Primary Pulmonary Hypertension 01/2021
1	Substance-Related Disorders (Drug Abuse) 01/2021
1	Parasomnias (Parasomnia) 11/2020
1	Mania (Manias) 06/2020

Drug/Important Bio-Agent (IBA)

43	OrexinsIBA 01/2021 - 06/2002
23	Endothelin-1 (Endothelin 1)IBA 01/2016 - 08/2002
14	NeuropeptidesIBA 12/2016 - 06/2002
13	Endothelins (Endothelin)IBA 12/2019 - 04/2002
11	Orexin ReceptorsIBA 01/2022 - 03/2004
9	Peptides (Polypeptides)IBA 01/2021 - 04/2003
8	Glucose (Dextrose)FDA LinkGeneric 12/2019 - 05/2003
7	Proteins (Proteins, Gene)FDA Link 12/2020 - 01/2002
7	Endothelin B ReceptorIBA 08/2006 - 04/2002
6	Messenger RNA (mRNA)IBA 12/2020 - 04/2002
6	Endothelin Receptors (Endothelin Receptor)IBA 12/2019 - 01/2010
6	Insulin (Novolin)FDA Link 11/2016 - 05/2003
5	Ataxin-3IBA 03/2010 - 05/2004
4	Pharmaceutical PreparationsIBA 01/2019 - 10/2012
4	LeptinIBA 01/2012 - 03/2004
4	SaltsIBA 08/2008 - 05/2003
3	Orexin Receptor AntagonistsIBA 01/2021 - 01/2019
3	suvorexantIBA 01/2021 - 11/2016
3	Endothelin Receptor AntagonistsIBA 11/2017 - 08/2008
3	CollagenIBA 01/2016 - 10/2012
3	Cholinergic Agents (Cholinergics)IBA 01/2016 - 04/2011
3	Streptozocin (Streptozotocin)FDA Link 05/2014 - 04/2006
3	ReninIBA 04/2006 - 08/2004
3	A 192621IBA 01/2005 - 09/2002
2	LipopolysaccharidesIBA 10/2022 - 12/2016
2	Dopamine (Intropin)FDA LinkGeneric 06/2020 - 08/2011
2	AutoantibodiesIBA 12/2019 - 01/2009
2	AntibodiesIBA 12/2019 - 08/2013
2	YNT-185IBA 11/2018 - 01/2017
2	CytokinesIBA 12/2016 - 01/2016
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2016 - 01/2014
2	Drinking WaterIBA 01/2016 - 04/2004
2	Connective Tissue Growth FactorIBA 01/2014 - 10/2012
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2012 - 10/2004
2	Superoxides (Superoxide)IBA 04/2012 - 06/2010
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2012 - 12/2003
2	LigandsIBA 09/2006 - 08/2004
2	SodiumIBA 04/2006 - 08/2004
2	4-nitrophenethyl bromide (NPB)IBA 07/2005 - 05/2003
2	AtrasentanIBA 01/2005 - 08/2004
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 08/2004 - 06/2003
1	Sevoflurane (Ultane)FDA LinkGeneric 10/2022
1	Nonesterified Fatty Acids (NEFA)IBA 03/2022
1	Amyloid beta-PeptidesIBA 03/2022
1	Hormones (Hormone)IBA 01/2021
1	Inhibins (Inhibin)IBA 01/2021
1	activin AIBA 01/2021
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2021
1	AcidsIBA 12/2020
1	AMPA Receptors (AMPA Receptor)IBA 12/2020
1	Transcription Factors (Transcription Factor)IBA 11/2020
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 06/2020

Therapy/Procedure

10	Therapeutics 01/2020 - 01/2006
2	Ligation 04/2009 - 10/2002